ULTIMO AGGIORNAMENTO BANCA DATI: 07/11/2025 14:33:35
Background Several c-MET targeting inhibitory molecules have already shown promising results in the treatment of patients with Non-small Cell Lung Cancer (NSCLC). Combination of EGFR- and c-MET-specific molecules may overcome EGFR tyrosine kinase inhibitor (TKI) resistance. The aim of this study was ...
Merkel cell polyomavirus (MCPyV) is considered the etiological agent of Merkel cell carcinoma and persists asymptomatically in the majority of its healthy hosts. Largely due to the lack of appropriate model systems, the mechanisms of viral replication and MCPyV persistence remain poorly understood. ...
Bivalve shell is a biomineralized tissue with various layers/microstructures and excellent mechanical properties. Shell matrix proteins (SMPs) pervade and envelop the mineral crystals and play essential roles in biomineralization. Despite that Mytilus is an economically important bivalve, only few proteomic ...
Background Considerable effort has been made to categorise the bacterial composition of the human gut and correlate findings with gastrointestinal disease. The infant gut has long been considered sterile at birth followed by rapid colonisation; however, this view has recently been challenged. We examined ...
Patient-derived cancer xenografts (PDCX) generally represent more reliable models of human disease in which to evaluate a potential drugs preclinical efficacy. However to date, only a few patient-derived gastric cancer xenograft (PDGCX) models have been reported. In this study, we aimed to establish ...
Carbonic anhydrase related proteins (CARPs) X and XI are highly conserved across species and are predominantly expressed in neural tissues. The biological role of these proteins is still an enigma. Ray-finned fish have lost the CA11 gene, but instead possess two co-orthologs of CA10. We analyzed the ...
Coastal degradation and habitat disruption are severely compromising sessile marine species. The fan shell Pinna nobilis is an endemic, vulnerable species and the largest bivalve in the Mediterranean basin. In spite of species legal protection, fan shell populations are declining. Models analyzed the ...
Abstract Recent years, the single-point mooring cage system has received much more attention because of their eco-friendly characteristics. Numerical simulation is performed to analyze the hydrodynamic behavior of a self-submersible single-point mooring gravity cage in waves and current. The effect ...
Abstract Offshore cages are designed to avoid further negative environmental damage in the coastal area while enable sustainable aquaculture growth. However, little is known about the environmental impact from this culturing activity in China. The objective of this study is to simulate the environmental ...
Abstract This paper describes online simultaneous underwater image gathering, utilizing stationary camera node and movable camera node. We consider applying them to investigate the conditions of marine ecosystem around coral leaf at Okinawa, Japan. The framework of our proposed underwater image gathering ...
Abstract Aquaculture cage systems are affected by various external forces from the ocean environment. Movements and deformation of netting can damage its structure and rearing species. Biofouling on synthetic fiber nets is a major concern for marine aquaculture systems because, it increases the net ...
Abstract Benten River has a floodgate for disaster prevention. We have investigated the effect of the water supply from Benten River due to the floodgate opening on the water qualities in Shido Bay. Average values of salinity, turbidity and chlorophyll a to the deep direction at the inner bay were ...
Abstract This paper investigated the performance of sustainability of a conceptual offshore platform that integrated renewable energy utilization and microalgae bio-fuel production in East China Sea. Triple I light (III light), which is calculated based on ecological footprint, bio-capacity, cost and ...
Abstract The aim of this paper is to study anchor handling vessel (AHV) thrust capacity during anchor deployment. The thrust utilisation plot, a concept widely used in the Dynamic Positioning (DP) system, is used to illustrate the positioning capability of an AHV. Bollard pull reduction due to heavy ...
Abstract Naturally occurring shoals and near-shore reefs act as good wave attenuators. Artificial creations of such nature identical attenuators are called artificial reefs. They are being increasingly deployed since the past decade, as artificial reefs may be included under soft engineering approach ...
Abstract In this paper, results from comparisons of simulations and measured offshore data from a floating combined wind and wave energy conversion system are presented. The device is a downscaled prototype that consists of a floating platform equipped with ten wave energy absorbers and three wind ...
Abstract Red tides off the Japanese coast caused serious damages to aquaculture industries in every year (Honjo 1994). To reduce fisheries damage due to red tide, it is important to inform aquaculturist of red tides in short-term scale distribution. We developed a monitoring system which collects real-time ...
Abstract The transport of pollutant is an important topic for self-purification capability and environment evaluation of ocean. Chemical oxygen demand (COD, determined by potassium permanganate) is selected as a key parameter to indicate the water pollution degree. This study employs field measurements ...
Abstract Two self reacting point absorber (SRPA) wave energy converter (WEC) design configurations are under analysis by the West Coast Wave Initiative (WCWI) at the University of Victoria. The analyses are motivated threefold. First, to provide benchmark comparisons of the two SRPA configurations ...
Cryptosporidium, a protozoan parasite that can cause severe diarrhea in a wide range of vertebrates including humans, is increasingly recognized as a parasite of a diverse range of wildlife species. However, little data are available regarding the identification of Cryptosporidium species and genotypes ...